Differin / Third-Generation Retinoid
Third-generation synthetic retinoid — selective for RARβ and RARγ subtypes and photostable. Originally prescription-only Differin, now OTC at 0.1%. FDA-approved for acne with emerging evidence for anti-aging. Most tolerable prescription-class retinoid — better suited than tretinoin for sensitive or easily irritated skin.
PM only, 0.1% gel OTC or 0.3% prescription. Pea-sized amount for entire face. Build slowly, 2–3x per week to start. Strict daily SPF required.
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