Type I / III / IV Collagen / Extracellular Matrix
The most abundant protein in the human body — accounting for approximately 80% of the dermis by dry weight. Skin collagen is primarily Type I (providing tensile strength) and Type III (providing elasticity). Synthesised by dermal fibroblasts and assembled into triple-helix fibrils, collagen creates the structural scaffold that keeps skin firm and plump. Collagen production peaks in the mid-20s then declines at approximately 1% per year; UV radiation, smoking and high blood sugar (glycation) dramatically accelerate degradation.
Topical ingredients cannot directly add collagen to skin (molecules are too large). Instead, they stimulate fibroblasts (retinoids, peptides) or protect existing collagen from degradation (antioxidants, SPF). Oral collagen peptides may indirectly stimulate fibroblast activity.
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